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Sally Marshall, Editor Investigators, patients and their families, and the public all wish for research to advance, to enable us to prevent or cure human type 1 diabetes.

There has been much progress towards potentially achieving this; yet, there are a number of issues associated with conducting and reporting studies in this area.

Asico, Xiaobo Ma, Ines Armando, Hironobu Sanada, Minoru Yoneda, Robin A.

Sadly, headlines often overstate results and give hype to advances that are but one small step on the road to achievement of a clinically meaningful outcome.

In the present issue of Diabetologia, Soulage et al report that 4-HHE is associated with type 2 diabetes and plays a causal role in the development of insulin resistance in skeletal muscle.

Cover credit: Design by Csil (Cécile Pillon Hue, under the Creative Commons Attribution-Non Commercial 4.0 International (CC BY-NC 4.0; Competition for publication in Diabetologia is greater than ever, and less than 20% of papers are accepted.[Text supplied by the authors.] Download a pdf **************************** The blood pressure targets to pursue with antihypertensive treatment are the subject of continuing debate.

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Iran (Islamic Republic of) Criteria: (iii)(v) The City of Yazd is located in the middle of the Iranian plateau, 270 km southeast of Isfahan, close to the Spice and Silk Roads.

Excavated from the 1860s, six caves have revealed items dating from 43,000 to 33,000 years ago.

It bears witness to the cultural histories of the Norse farmer-hunters who started arriving from Iceland in the 10th century and of the Inuit hunters and Inuit farming communities that developed from the end of the 18th century.

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